Coexistencia entre polimiositis y enfermedad de Castleman; presentación de un caso.

Antonio Wong, Rosa Barbosa Cobos, Cristina Cuesta Mejias, Karla Campozano Vásquez

Resumen


La coexistencia entre la enfermedad de Castleman y polimiopatia inflamatoria idiopática es poco conocida por cuanto existe pocos casos referentes a estas dos patologías juntas. Las características histopatológicas de los nódulos linfáticos asociados en estas dos entidades son similares, haciendo su diferenciación más difícil. La resolución quirúrgica del tumor conlleva, en la mayoría de casos a la mejoría de las manifestaciones autoinmunes, aunque en ciertos casos, el uso de glucocorticoides, radioterapia, quimioterapia y tratamiento biológicos pueden ser usados cuando la opción quirúrgica no es suficiente. Se propone como parte de la fisiopatología de la enfermedad de Castleman, compartida en ciertas enfermedades autoinmunes, la inmunoactivación celular asociada con niveles altos de interleukina 6 y otros reactantes de fase aguda, así como ciertos procesos infecciosos como el virus de inmunodeficiencia adquirida y el virus del Epstein-Barr. Se presenta el caso de una mujer de 17 años con diagnóstico de enfermedad de Castleman variante hialino vascular y polimiositis.

Palabras clave


hiperplasia de ganglio linfático gigante; ganglios linfáticos; miositis. giant lymph node hyperplasia; lymph nodes; myositis.

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Referencias


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DOI: http://dx.doi.org/10.23878/medicina.v19i1.632



Revista Medicina - Universidad Católica de Santiago de Guayaquil - Facultad de Ciencias Médicas