Patogénesis de dengue: consideraciones moleculares.

Eduardo Tarquino Jurado Cobeña, Mary Ernestina Regato Arrata

Resumen


El virus dengue es el arbovirus de mayor importancia a nivel mundial; alrededor de 2 500 millones de personas viven en más de 100 países endémicos. Hasta 50 millones de infecciones ocurren anualmente con 500 000 casos de fiebre hemorrágica por dengue y 22 000 muertes principalmente entre niños. En el Ecuador el dengue es una enfermedad endémica y los cuatro serotipos se encuentran circulando. Este trabajo hace una breve revisión bibliográfica de las bases moleculares de la patogenicidad; así como también de las interacciones inmunológicas moleculares virus-huésped, haciendo énfasis en los hallazgos más importantes tanto a nivel experimental cuanto a nivel clínico, finalmente se discuten las perspectivas del conocimiento actual.

Palabras clave


dengue; patogenicidad; patología molecular. dengue; pathogenicity; pathology molecular.

Texto completo:

PDF

Referencias


Westaway, E. G. et al. Flaviviridae. Intervirology 24, 183–192 (1985).

WHO | Impact of Dengue. WHO at

Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504–507 (2013).

Álava, A., Mosquera, C., Mosquera, C., Vargas, W. & Real, J.

Dengue en el Ecuador 1989-2002. Rev. Ecuat. Hig. Med. Trop. 42, 11–34 (2005).

Francis, T. J. On the doctrine of original antigenic sin. Proc. Am. Philos. Soc. 104, 572–578 (1960).

Paul, J. R. Thomas Francis, Jr., 1900-1969: A Biographical Memoir. (National Academy of Sciences, 1974).

Beyer, W. E., de Bruijn, I. A., Palache, A. M., Westendorp, R. G. & Osterhaus, A. D. The plea against annual influenza vaccination? ‘The Hoskins’ Paradox’ revisited. Vaccine 16, 1929–1932 (1998).

Zompi, S. & Harris, E. Original antigenic sin in dengue revisited. Proc. Natl. Acad. Sci. 110, 8761–8762 (2013).

Guzman, M. G., Alvarez, M. & Halstead, S. B. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch. Virol. 158, 1445–1459 (2013).

Modhiran, N., Kalayanarooj, S. & Ubol, S. Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse. PLoS Negl Trop Dis 4, e924 (2010).

Perera-Lecoin, M., Meertens, L., Carnec, X. & Amara, A. Flavivirus Entry Receptors: An Update. Viruses 6, 69–88 (2013).

Sun, P. & Kochel, T. J. The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis. Sci. World J. 2013, (2013).

Tsai, T.-T. et al. An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection. J. Biomed. Sci. 20, 40 (2013).

Mondotte, J. A., Lozach, P.-Y., Amara, A. & Gamarnik, A. V. Essential Role of Dengue Virus Envelope Protein N Glycosylation at Asparagine-67 during Viral Propagation. J. Virol. 81, 7136–7148 (2007).

Mota, J. & Rico-Hesse, R. Dengue Virus Tropism in Humanized Mice Recapitulates Human Dengue Fever. PLoS ONE 6, e20762 (2011).

Silveira, G. F. et al. Dengue Virus Type 3 Isolated from a Fatal Case with Visceral Complications Induces Enhanced Proinflammatory Responses and Apoptosis of Human Dendritic Cells. J. Virol. 85, 5374–5383 (2011).

Avirutnan, P. et al. Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J. Immunol. Baltim. Md 1950 187, 424–433 (2011).

Marinho, C. F. et al. Down-Regulation of Complement Receptors on the Surface of Host Monocyte Even as In Vitro Complement Pathway Blocking Interferes in Dengue Infection. PLoS ONE 9, (2014).

Matangkasombut, P. et al. Invariant NKT Cell Response to Dengue Virus Infection in Human. PLoS Negl. Trop. Dis. 8, (2014).

Rivino, L. et al. Differential Targeting of Viral Components by CD4+ versus CD8+ T Lymphocytes in Dengue Virus Infection. J. Virol. 87, 2693–2706 (2013).

Weiskopf, D. & Sette, A. T-cell immunity to infection with dengue virus in humans. Front. Immunol. 5, 93 (2014).

Weiskopf, D. et al. Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells. Proc. Natl. Acad. Sci. 110, E2046–E2053 (2013).

Rathakrishnan, A. et al. Clinical and Immunological Markers of Dengue Progression in a Study Cohort from a Hyperendemic Area in Malaysia. PLoS ONE 9, (2014).

Monteiro, S. P. et al. HLA-A* 01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population. Mem. Inst. Oswaldo Cruz 107, 224–230 (2012).

Fernández-Mestre, M. et al. HLA Alleles and Dengue Virus Infection in Venezuelan Patients: A Preliminary Study. Inmunología 28, 96–100 (2009).

Ng, J. K. W. et al. First Experimental In Vivo Model of Enhanced Dengue Disease Severity through Maternally Acquired Heterotypic Dengue Antibodies. PLoS Pathog. 10, (2014).

Richter, M. K. S. et al. Immature Dengue Virus Is Infectious in Human Immature Dendritic Cells via Interaction with the Receptor Molecule DC-SIGN. PLoS ONE 9, (2014).

Rajapakse, S., Rodrigo, C., Maduranga, S. & Rajapakse, A. C. Corticosteroids in the treatment of dengue shock syndrome. Infect. Drug Resist. 7, 137–143 (2014).

Senthilvel, P. et al. Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents Dengue 2 viral assembly. Bioinformation 9, 889–895 (2013).

De La Guardia, C. & Lleonart, R. Progress in the Identification of Dengue Virus Entry/Fusion Inhibitors. BioMed Res. Int. 2014, (2014).

Whitehorn, J. et al. Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions. PLoS Negl. Trop. Dis. 8, (2014).

Khadka, S. et al. A Physical Interaction Network of Dengue Virus and Human Proteins. Mol. Cell. Proteomics 10, M111.012187 (2011).

Hidari, K. I. P. J. & Suzuki, T. Dengue virus receptor. Trop.

Med. Health 39, 37–43 (2011).

Yeo, A. S. L. et al. Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes. PLoS ONE 9, (2014).

Guzmán, M. G. et al. Dr. Guzmán et al. Respond to Dr. Vaughn. Am. J. Epidemiol. 152, 804–804 (2000).

Back, A. T. & Lundkvist, A. Dengue viruses -an overview. Infect. Ecol. Epidemiol. 3, (2013).

Valdez, M. R. W. de et al. Genetic elimination of dengue vector mosquitoes. Proc. Natl. Acad. Sci. 108, 4772–4775 (2011).

Lan, N. T. P. & Hirayama, K. Host genetic susceptibility to severe dengue infection. Trop. Med. Health 39, 73–81 (2011).




DOI: http://dx.doi.org/10.23878/medicina.v19i1.742



Revista Medicina - Universidad Católica de Santiago de Guayaquil - Facultad de Ciencias Médicas